Sodium iodate induced retinal degeneration: new insights from an old model
نویسندگان
چکیده
منابع مشابه
Protection of Retina by αB Crystallin in Sodium Iodate Induced Retinal Degeneration
Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. The retinal pigment epithelium (RPE) is a critical site of pathology in AMD and αB crystallin expression is increased in RPE and associated drusen in AMD. The purpose of this study was to investigate the role of αB crystallin in sodium iodate (NaIO3)-induced retinal degeneration, a model of AMD in whi...
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Green tea extracts exhibit anti-oxidative and anti-inflammatory actions in different disease conditions. We hypothesized that green tea extract and its catechin constituents ameliorate sodium iodate-induced retinal degeneration in rats by counteracting oxidative stress. In this study, adult Sprague-Dawley rats were intravenously injected with a single dose of sodium iodate. Green tea extract (G...
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متن کاملExperimental Pigmentary Degeneration of the Retina by Sodium Iodate.
SEPTOJOD,* which appears to have been introduced in 1920, has been used widely in German-speaking countries for septic conditions on the assumption that nascent iodine is liberated by this preparation in the presence of septic material. It has been especially popular in the treatment of puerperal sepsis. In 1926, Schimmel and Riehm reported two cases of blindness following the intravenous injec...
متن کاملDecreased visual function after patchy loss of retinal pigment epithelium induced by low-dose sodium iodate.
PURPOSE To correlate damage to the retinal pigment epithelium (RPE) with decreased visual function after the systemic administration of sodium iodate (NaIO(3)). METHODS Damage was produced in mice by injection of 15, 25, or 35 mg/kg NaIO(3). Visual function was assessed with the cued water maze (WM) behavioral test and the optokinetic reflex (OKR) measurement at different times after injectio...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2014
ISSN: 1673-5374
DOI: 10.4103/1673-5374.147927